Garcovich A, Pagano L, Storti S, Paoletti S, Piscitelli R, Sica S, Marra R
Panminerva Med. 1989 Apr-Jun;31(2):76-9.
Thirty-five patients affected by Progressive System Sclerosis (PSS) (20 acrosclerosis and 15 diffuse sclerosis) were subjected to the following laboratory tests: Beta 2 microglobulin (B2m), Fibronectin, C3c, C4, Fibrinogen, Factor VIII Coagulant (F. VIII:C), Factor VIII related Antigen (F. VIII:Ag), IgG, ESR, Antithrombin III (AT III), alpha 1 Antitrypsin (alpha 1AT) and alpha 2 Macroglobulin (alpha 2M). The results showed that no difference was observed between the normal group and the groups of PSS patients with respect to alpha 1AT, alpha 2M, and AT III. In contrast the B2m, ESR, IgG, F. VIII:Ag results were significantly higher in the PSS patients, while Fibrinogen and C3c results were slightly higher, but no high enough to be of statistical significance. The two PSS patient subgroups did not produce significant results, only the C4 values were lower in the Diffuse Sclerosis subgroup. From these results it seem that the tests used are not very useful indifferentiating the two subgroups of the PSS patients.
35例进行性系统性硬化症（PSS）患者（20例肢端硬化症和15例弥漫性硬化症）接受了以下实验室检查：β2微球蛋白（B2m）、纤连蛋白、C3c、C4、纤维蛋白原、凝血因子VIII（F.VIII:C）、凝血因子VIII相关抗原（F.VIII:Ag）、IgG、红细胞沉降率（ESR）、抗凝血酶III（AT III）、α1抗胰蛋白酶（α1AT）和α2巨球蛋白（α2M）。结果显示，在α1AT、α2M和AT III方面，正常组与PSS患者组之间未观察到差异。相比之下，PSS患者的B2m、ESR、IgG、F.VIII:Ag结果显著更高，而纤维蛋白原和C3c结果略高，但未高到具有统计学意义。两个PSS患者亚组未产生显著结果，仅弥漫性硬化症亚组的C4值较低。从这些结果来看，所使用的检查似乎对区分PSS患者的两个亚组不太有用。
