Topper M J, Prasse K W
Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Am J Vet Res. 1998 May;59(5):542-5.
To measure coagulation factor VIII:coagulant (F.VIII:C) and C1-esterase inhibitor (C1-INH), hemostasis-associated acute-phase reactant proteins and coagulation factors VII (F.VII), IX (F.IX), and X (F.X), hemostasis proteins not associated with an acute-phase response, in a select population of horses with colic and hemostasis abnormalities, and presumed to have acute-phase changes. To compare these values and other routine hemostasis test results in the horses with colic with values for a population of healthy horses. To correlate the values of known equine acute-phase reactants, F.VIII:C and fibrinogen, to those of other tests of hemostasis. To identify hemostasis-associated acute-phase reactant proteins and gain insights into the effects the acute-phase response has on hemostatic abnormalities in horses with colic syndrome.
54 plasma samples from horses with colic attributable to inflammatory (n = 39) or strangulating (n = 15) intestinal disorders.
Plasma samples were evaluated for activities of F.VII, F.VIII:C, F.IX, F.X, C1-INH, antithrombin III, protein C, plasminogen, and alpha 2-antiplasmin (alpha 2AP); fibrinogen concentration; and prothrombin (PT) and activated partial thromboplastin (APTT) times.
Horses with colic had significantly higher fibrinogen concentration, greater alpha 2AP and protein C activities, and longer PT and APTT than did healthy horses. Horses with colic also had significantly lower mean F.VII activity than did healthy horses. Significant positive correlations between fibrinogen concentration and F.VIII:C, C1-INH, and alpha 2AP values, and between F.VIII:C activity and fibrinogen, C1-INH, alpha 2AP, and plasminogen values were identified.
An acute-phase response contributes to changes observed in coagulation proteins in horses with colic attributable to inflammatory and strangulating intestinal disorders. The data suggest that plasminogen, alpha 2AP, and C1-INH, should be considered equine acute-phase proteins.
测定患有绞痛且存在止血异常、推测有急性期变化的特定马群中凝血因子VIII：促凝剂（F.VIII:C）和C1酯酶抑制剂（C1-INH）、与止血相关的急性期反应蛋白以及凝血因子VII（F.VII）、IX（F.IX）和X（F.X）（与急性期反应无关的止血蛋白）。比较这些患有绞痛的马的数值及其他常规止血测试结果与健康马群的数值。将已知的马急性期反应物F.VIII:C和纤维蛋白原的数值与其他止血测试的数值相关联。识别与止血相关的急性期反应蛋白，并深入了解急性期反应对患有绞痛综合征的马的止血异常的影响。
54份来自患有因炎症性（n = 39）或绞窄性（n = 15）肠道疾病引起绞痛的马的血浆样本。
评估血浆样本中F.VII、F.VIII:C、F.IX、F.X、C1-INH、抗凝血酶III、蛋白C、纤溶酶原和α2抗纤溶酶（α2AP）的活性；纤维蛋白原浓度；以及凝血酶原（PT）和活化部分凝血活酶（APTT）时间。
患有绞痛的马的纤维蛋白原浓度显著更高，α2AP和蛋白C活性更高，PT和APTT比健康马更长。患有绞痛的马的平均F.VII活性也显著低于健康马。确定了纤维蛋白原浓度与F.VIII:C、C1-INH和α2AP值之间，以及F.VIII:C活性与纤维蛋白原、C1-INH、α2AP和纤溶酶原值之间存在显著正相关。
急性期反应导致了因炎症性和绞窄性肠道疾病引起绞痛的马的凝血蛋白变化。数据表明纤溶酶原、α2AP和C1-INH应被视为马的急性期蛋白。
