Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, Fujian, China.
Org Lett. 2016 Dec 16;18(24):6356-6359. doi: 10.1021/acs.orglett.6b03244. Epub 2016 Dec 2.
An efficient Rh(III)-catalyzed direct ortho-C-H olefination of acetanilides with vinyl acetate was developed. This protocol provides a straightforward pathway to a series of (E)-2-acetamidostyryl acetates, giving access to indole derivatives following a simple hydrolysis/cyclization process.
发展了一种高效的 Rh(III)-催化的乙酰苯胺与醋酸乙烯酯的直接邻位 C-H 烯烃化反应。该方案为一系列（E）-2-乙酰氨基苯乙烯基醋酸酯提供了一条直接途径，通过简单的水解/环化过程可以得到吲哚衍生物。
