通过钯催化的芳基化去芳构化/环扩张级联反应，从糠基环丁醇获得非对映选择性和对映选择性的双螺环氧化吲哚。
Diastereospecific and Enantioselective Access to Dispirooxindoles from Furfurylcyclobutanols by Means of a Pd-Catalyzed Arylative Dearomatization/Ring Expansion Cascade.
机构信息
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
出版信息
Org Lett. 2016 Dec 16;18(24):6440-6443. doi: 10.1021/acs.orglett.6b03339. Epub 2016 Dec 5.
PMID:27978697
Abstract
We report a Pd-catalyzed arylative dearomatization/ring expansion cascade of furfurylcyclobutanols that involves a spiro π-allyl palladium intermediate and affords structurally novel dispirooxindoles containing two quaternary carbon centers in good yields with high step economy, diastereospecificity, and enantioselectivity.
摘要
我们报告了一种钯催化的糠基环丁醇的芳基化去芳构化/环扩张级联反应，涉及到一个螺环π-烯丙基钯中间体，并以良好的收率、高步骤经济性、非对映选择性和对映选择性提供了结构新颖的含有两个季碳中心的双螺环氧吲哚。
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