Le Noc P, Croize J, Bryskier A, Le Noc D, Robert J
Service de Bactériologie et Virologie, Centre Hospitalier et Universitaire, Grenoble.
Pathol Biol (Paris). 1989 Jun;37(5 Pt 2):553-9.
The bacteriostatic and bactericidal activities of five macrolides (roxithromycin, erythromycin, troleandomycin, josamycin and spiramycin) were tested against 284 bacterial strains belonging to various species of Gram positive (staphylococci, streptococci, pneumococci, Listeria sp, Corynebacterium sp, Bacillus sp) and Gram negative bacteria (Neisseria sp, H. influenzae, P. multocida). The activity of these compounds on the whole strains showed near results: 71.8% of susceptible strains to erythromycin and spiramycin, 70% to josamycin, 67.6% to roxithromycin, 65.5% to troleandomycin. Resisting strains were MLSB resistant cocci Gram positive, H. influenzae and P. multocida strains. Species usually less studied (nongroupable streptococci, Corynebacterium sp, Bacillus sp) were very susceptible to macrolides with MICS equal or inferior to 1 mg/l for the two last genus. A bactericidal effect was observed for 38.8% of 72 tested strains (erythromycin), 36.1% (josamycin), 34.7% (spiramycin), 31.9% (roxithromycin), 20.8% (troleandomycin). Among various tested species, this bactericidal effect concerned especially group A streptococci, N. meningitidis and Corynebacterium (except D2 and JK species).
测试了五种大环内酯类药物（罗红霉素、红霉素、醋竹桃霉素、交沙霉素和螺旋霉素）对284株细菌的抑菌和杀菌活性，这些细菌分别属于革兰氏阳性菌（葡萄球菌、链球菌、肺炎球菌、李斯特菌属、棒状杆菌属、芽孢杆菌属）和革兰氏阴性菌（奈瑟菌属、流感嗜血杆菌、多杀巴斯德菌）的不同种。这些化合物对所有菌株的活性显示出相近的结果：对红霉素和螺旋霉素敏感的菌株占71.8%，对交沙霉素敏感的占70%，对罗红霉素敏感的占67.6%，对醋竹桃霉素敏感的占65.5%。耐药菌株为革兰氏阳性MLSB耐药球菌、流感嗜血杆菌和多杀巴斯德菌菌株。通常研究较少的菌种（不可分组链球菌、棒状杆菌属、芽孢杆菌属）对大环内酯类药物非常敏感，后两个属的最小抑菌浓度（MIC）等于或低于1mg/L。在72株受试菌株中，观察到具有杀菌作用的菌株比例分别为：红霉素38.8%、交沙霉素36.1%、螺旋霉素34.7%、罗红霉素31.9%、醋竹桃霉素20.8%。在各种受试菌种中，这种杀菌作用尤其涉及A组链球菌、脑膜炎奈瑟菌和棒状杆菌（除D2和JK菌种外）。
