Latrive J P, Barbare J C, Darchis J P, Farinotti R, Noel F
Service d'Hépatogastroentérologie, Centre Hospitalier de Compiègne, Compiègne.
Pathol Biol (Paris). 1989 Jun;37(5 Pt 2):635-7.
The ofloxacin diffusion was investigated in 13 cirrhotic patients with spontaneous bacterial peritonitis. Plasma and ascitic samples were collected at times H1, H31 and H8 after a first dose of 200 mg per os, in these 13 patients, after 4.5 or 6 days of 200 mg per os each 8 hours in 9 out of them. After the first dose, the plasmatic and ascitic concentrations, measured by High Performance Liquid Chromatography (HPLC), were between 0 and 3.62 mg/l, 0 and 1.95 mg/l respectively. The steady state concentrations are higher than the MIC'S for the organisms most commonly involved, comparable in the plasma and the ascitic fluid is good and suggest the interest of its use in this indication.
在13例自发性细菌性腹膜炎的肝硬化患者中研究了氧氟沙星的扩散情况。在这13例患者中，口服200mg首剂后，于H1、H31和H8时间点采集血浆和腹水样本，其中9例患者每8小时口服200mg，持续4.5或6天。首剂后，通过高效液相色谱法（HPLC）测定的血浆和腹水浓度分别在0至3.62mg/l、0至1.95mg/l之间。稳态浓度高于最常见相关病原体的最低抑菌浓度，血浆和腹水中的浓度相当良好，表明其在该适应症中的应用价值。
