Dickmann Leslie J, Ware Joseph A
Department of Clinical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Department of Clinical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Drug Discov Today Technol. 2016 Sep-Dec;21-22:11-16. doi: 10.1016/j.ddtec.2016.11.003.
The aim of personalized medicine is to offer the right treatment to the right person at the right dose, thus maximizing efficacy and minimizing toxicity for each individual patient. Pharmacogenomic approaches attempt to refine the aim of personalized medicine by utilizing an individual's germline and somatic DNA signatures to guide treatment. In this review, we highlight the current use of pharmacogenomic based biomarker information in drug labeling. We also present several case studies on the implementation of pharmacogenomic strategies in drug discovery and development. Lastly, we comment on current challenges to implementing pharmacogenomic based testing in the clinic.
个性化医疗的目标是在正确的时间，以正确的剂量为正确的患者提供恰当的治疗，从而使每位患者的疗效最大化，毒性最小化。药物基因组学方法试图通过利用个体的种系和体细胞DNA特征来指导治疗，从而完善个性化医疗的目标。在本综述中，我们重点介绍了基于药物基因组学的生物标志物信息在药物标签中的当前应用。我们还展示了几个在药物发现和开发中实施药物基因组学策略的案例研究。最后，我们对目前在临床中实施基于药物基因组学的检测所面临的挑战进行了评论。
