Piatowska D
Patol Pol. 1989;40(1):69-81.
Chronic periapical lesions were recognized clinically and radiologically in 109 patients aged from 10 to 79, twice as frequent in the maxilla as in the mandible. Histopathological analysis revealed periapical granulomas and cysts. Forty-eight periapical granulomas were studied histobacteriologically. Detailed microscopic analysis of these cases in order to find bacteria was negative. Histopathological analysis of 72 periapical granulomas and 13 cysts (including four follicular cysts) revealed mixed forms apart from homogenous granulomas. In addition changes in the composition of infiltrate cells are rather qualitative than quantitative, therefore classification of periapical lesions into periapical granulomas and cysts seems justified and sufficient for diagnostic and clinical needs. Detailed analysis of cellular composition of periapical granulomas and cysts shows that immunologic agents may play a role in the pathomechanism of these lesions.
109名年龄在10至79岁之间的患者经临床和影像学检查确诊为慢性根尖周病变，其中上颌病变的发生率是下颌的两倍。组织病理学分析显示为根尖周肉芽肿和囊肿。对48例根尖周肉芽肿进行了组织细菌学研究。为寻找细菌对这些病例进行的详细显微镜分析结果为阴性。对72例根尖周肉芽肿和13例囊肿（包括4例滤泡囊肿）的组织病理学分析显示，除了均质肉芽肿外，还有混合形式。此外，浸润细胞成分的变化更多是定性的而非定量的，因此将根尖周病变分为根尖周肉芽肿和囊肿似乎合理且足以满足诊断和临床需求。对根尖周肉芽肿和囊肿细胞成分的详细分析表明，免疫因子可能在这些病变的发病机制中起作用。
