Pringle G A, Daley T D, Veinot L A, Wysocki G P
Department of Pathology, University of Western Ontario, London, Canada.
Oral Surg Oral Med Oral Pathol. 1992 Aug;74(2):186-92. doi: 10.1016/0030-4220(92)90381-y.
This report describes a series of six cases of inflammatory periapical disease with small aggregates of Langerhans cells as a minor component. Immunohistochemical findings confirm that the cells are phenotypically related to Langerhans cells. Aggregates of these cells are not normally found in radicular cysts or periapical granulomas and have been interpreted to represent chronic localized Langerhans' cells histiocytosis. Whether these lesions, which arise within the context of chronic inflammatory periapical disease, represent incipient eosinophilic granulomas or are a more benign, minimally destructive form of Langerhans' cell histiocytosis is unknown. Clinical follow-up suggests that these lesions remain localized and that curettage is adequate treatment.
本报告描述了一系列6例炎症性根尖周疾病，其中小簇朗格汉斯细胞作为次要成分。免疫组织化学结果证实这些细胞在表型上与朗格汉斯细胞相关。这些细胞的聚集通常不见于根囊肿或根尖肉芽肿，被解释为代表慢性局限性朗格汉斯细胞组织细胞增生症。这些在慢性炎症性根尖周疾病背景下出现的病变是早期嗜酸性肉芽肿，还是朗格汉斯细胞组织细胞增生症的一种更良性、破坏性最小的形式，目前尚不清楚。临床随访表明，这些病变仍局限存在，刮治是充分的治疗方法。
