Nowacki P, Fryze C, Urasiński I, Wichert K
Patol Pol. 1989;40(1):99-107.
On the basis of neuropathologic studies in 22 patients died from ML it was found that lymphoma cells in the brain and spinal cord were in the form of leukostasis, infiltrations usually limited to perivascular spaces, infiltrations in hemorrhagic foci and their vicinity. In cerebrospinal meninges, spinal roots and peripheral nerves we observed leukostasis and intraparenchymatous infiltrations. It was found that the most important role in the development of lymphoma infiltrations in the nervous system was played by hematogenic metastases whose development in the brain and spinal cord was promoted by leukemic conversion with high leukocytosis. In contrast, marked dissemination of lymphoma cells to peripheral blood is not indispensible for the development of infiltrations in the cerebrospinal meninges and peripheral nervous system.
基于对22例死于髓系白血病（ML）患者的神经病理学研究发现，脑和脊髓中的淋巴瘤细胞呈白细胞淤滞形式，浸润通常局限于血管周围间隙、出血灶及其附近。在脑脊膜、脊神经根和周围神经中，我们观察到白细胞淤滞和实质内浸润。结果发现，血液转移在神经系统淋巴瘤浸润的发生中起最重要作用，而高白细胞血症导致的白血病转化促进了其在脑和脊髓中的发展。相比之下，淋巴瘤细胞向外周血的明显播散对于脑脊膜和周围神经系统浸润的发生并非必不可少。
