Su M-Y, Broadhurst M, Liu C-P, Gathercole J, Cheng W-L, Qi X-Y, Clerens S, Dyer J M, Day L, Haigh B
State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd., Shanghai, China.
AgResearch Ltd, Ruakura Research Centre, Hamilton, New Zealand.
Food Chem. 2017 Apr 15;221:1895-1903. doi: 10.1016/j.foodchem.2016.10.041. Epub 2016 Oct 12.
It has long been recognised that there are differences between human milk and infant formulas which lead to differences in health and nutrition for the neonate. In this study we examine and compare the peptide profile of human milk and an exemplar infant formula. The study identifies both similarities and differences in the endogenous and postdigestion peptide profiles of human milk and infant formula. This includes differences in the protein source of these peptides but also with the region within the protein producing the dominant proteins. Clustering of similar peptides around regions of high sequence identity and known bioactivity was also observed. Together the data may explain some of the functional differences between human milk and infant formula, while identifying some aspects of conserved function between bovine and human milks which contribute to the effectiveness of modern infant formula as a substitute for human milk.
长期以来，人们已经认识到母乳和婴儿配方奶粉之间存在差异，这些差异会导致新生儿在健康和营养方面的不同。在本研究中，我们检测并比较了母乳和一种典型婴儿配方奶粉的肽谱。该研究确定了母乳和婴儿配方奶粉在内源性和消化后肽谱方面的异同。这包括这些肽的蛋白质来源差异，以及产生主要蛋白质的蛋白质区域差异。还观察到相似肽在高序列同一性和已知生物活性区域周围的聚集。这些数据共同解释了母乳和婴儿配方奶粉之间的一些功能差异，同时确定了牛乳和母乳之间保守功能的一些方面，这些方面有助于现代婴儿配方奶粉作为母乳替代品的有效性。
