Yun Eun Ju, Lee Ah Reum, Kim Jung Hyun, Cho Kyung Mun, Kim Kyoung Heon
Department of Biotechnology, Graduate School, Korea University, Seoul 02841, South Korea.
Department of Biotechnology, Graduate School, Korea University, Seoul 02841, South Korea.
Food Chem. 2017 Apr 15;221:976-983. doi: 10.1016/j.foodchem.2016.11.066. Epub 2016 Nov 16.
The significance for anticariogenic sugar substitutes is growing due to increasing demands for dietary sugars and rising concerns of dental caries. Xylitol is widely used as an anticariogenic sugar substitute, but the inhibitory effects of xylitol on Streptococcus mutans, the main cause of tooth decay, are exhibited only at high concentrations. Here, the inhibitory effects of 3,6-anhydro-l-galactose (AHG), a rare sugar from red macroalgae, were evaluated on S. mutans, in comparison with those of xylitol. In the presence of 5g/l of AHG, the growth of S. mutans was retarded. At 10g/l of AHG, the growth and acid production by S. mutans were completely inhibited. However, in the presence of xylitol, at a much higher concentration (i.e., 40g/l), the growth of S. mutans still occurred. These results suggest that AHG can be used as a new anticariogenic sugar substitute for preventing dental caries.
由于对膳食糖的需求增加以及对龋齿的担忧日益加剧，防龋糖替代品的重要性日益凸显。木糖醇被广泛用作防龋糖替代品，但木糖醇对致龋主要原因变形链球菌的抑制作用仅在高浓度时才会表现出来。在此，与木糖醇相比，评估了一种来自红色大型藻类的稀有糖——3,6-脱水-L-半乳糖（AHG）对变形链球菌的抑制作用。在存在5g/L AHG的情况下，变形链球菌的生长受到抑制。在10g/L AHG时，变形链球菌的生长和产酸被完全抑制。然而，在存在木糖醇的情况下，在高得多的浓度（即40g/L）下，变形链球菌仍会生长。这些结果表明，AHG可作为一种新型防龋糖替代品用于预防龋齿。
