Fernandez-Moure Joseph S, Van Eps Jeffrey L, Cabrera Fernando J, Barbosa Zonia, Medrano Del Rosal Guillermo, Weiner Bradley K, Ellsworth Warren A, Tasciotti Ennio
Department of Surgery, Houston Methodist Hospital, Houston, Texas; Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas.
Department of Surgery, Houston Methodist Hospital, Houston, Texas; Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas.
J Surg Res. 2017 Jan;207:33-44. doi: 10.1016/j.jss.2016.08.063. Epub 2016 Aug 26.
Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodulation, and antiseptic properties. As the field of surgery continues to evolve so does the need for therapies to aid in treating the increasingly complex patients seen. With over 14 million obstetric, musculoskeletal, and urological and gastrointestinal surgeries performed annually, the healing of surgical wounds continues to be of upmost importance to the surgeon and patient. Platelet-rich plasma, or platelet concentrate, has emerged as a possible adjuvant therapy to aid in the healing of surgical wounds and injuries. In this review, we will discuss the wound healing properties of platelet-rich plasma and various surgical applications.
血小板是巨核细胞响应各种生理触发因素而释放的小的无核细胞质细胞体。传统上认为血小板仅参与止血机制，但由于其在伤口愈合、免疫调节和抗菌特性方面的作用，已备受关注。随着外科领域不断发展，对于辅助治疗日益复杂患者的疗法需求也在增加。每年进行超过1400万例产科、肌肉骨骼、泌尿外科和胃肠道手术，手术伤口的愈合对外科医生和患者来说仍然至关重要。富血小板血浆，即血小板浓缩物，已成为一种可能有助于手术伤口和损伤愈合的辅助治疗方法。在本综述中，我们将讨论富血小板血浆的伤口愈合特性及各种外科应用。
