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2005年和2008年在挪威萨尔普斯堡/腓特烈斯塔发生的两起并列的军团病疫情中分离出的6株嗜肺军团菌的全基因组序列

Complete Genome Sequences of Six Legionella pneumophila Isolates from Two Collocated Outbreaks of Legionnaires' Disease in 2005 and 2008 in Sarpsborg/Fredrikstad, Norway.

作者信息

Dybwad Marius, Aarskaug Tone, Fykse Else-Marie, Henie Madslien Elisabeth, Blatny Janet Martha

机构信息

Norwegian Defence Research Establishment FFI, Kjeller, Norway

Norwegian Defence Research Establishment FFI, Kjeller, Norway.

出版信息

Genome Announc. 2016 Dec 15;4(6):e01367-16. doi: 10.1128/genomeA.01367-16.

DOI:10.1128/genomeA.01367-16
PMID:27979936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5159569/
Abstract

Here, we report the complete genome sequences of Legionella pneumophila isolates from two collocated outbreaks of Legionnaires' disease in 2005 and 2008 in Sarpsborg/Fredrikstad, Norway. One clinical and two environmental isolates were sequenced from each outbreak. The genome of all six isolates consisted of a 3.36 Mb-chromosome, while the 2005 genomes featured an additional 68 kb-episome sharing high sequence similarity with the L. pneumophila Lens plasmid. All six genomes contained multiple mobile genetic elements including novel combinations of type-IVA secretion systems. A comparative genomics study will be launched to resolve the genetic relationship between the L. pneumophila isolates.

摘要

在此，我们报告了2005年和2008年在挪威萨尔普斯堡/腓特烈斯塔同时发生的两起军团病疫情中嗜肺军团菌分离株的全基因组序列。每次疫情均对1株临床分离株和2株环境分离株进行了测序。所有6株分离株的基因组均由一条3.36 Mb的染色体组成，而2005年分离株的基因组还有一个额外的68 kb附加体，与嗜肺军团菌Lens质粒具有高度序列相似性。所有6个基因组都包含多个可移动遗传元件，包括IVA型分泌系统的新组合。将开展一项比较基因组学研究，以解析嗜肺军团菌分离株之间的遗传关系。

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本文引用的文献

1
Molecular epidemiology, phylogeny and evolution of Legionella.嗜肺军团菌的分子流行病学、系统发育与进化
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The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae.嗜肺军团菌的 CRISPR 相关基因 cas2 是其感染变形虫的必需基因。
mBio. 2013 Mar 12;4(2):e00074-13. doi: 10.1128/mBio.00074-13.
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Molecular characterization of clinical and environmental isolates of Legionella pneumophila in Norway, 2001-2008.2001 - 2008年挪威嗜肺军团菌临床及环境分离株的分子特征分析
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Nat Genet. 2004 Nov;36(11):1165-73. doi: 10.1038/ng1447. Epub 2004 Oct 3.
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Infect Immun. 2001 Jan;69(1):508-17. doi: 10.1128/IAI.69.1.508-517.2001.

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