Strollo Sara, Lionakis Michail S, Adjemian Jennifer, Steiner Claudia A, Prevots D Rebecca
Emerg Infect Dis. 2016 Jan;23(1):7-13. doi: 10.3201/eid2301.161198.
Invasive candidiasis is a major nosocomial fungal disease in the United States associated with high rates of illness and death. We analyzed inpatient hospitalization records from the Healthcare Cost and Utilization Project to estimate incidence of invasive candidiasis-associated hospitalizations in the United States. We extracted data for 33 states for 2002-2012 by using codes from the International Classification of Diseases, 9th Revision, Clinical Modification, for invasive candidiasis; we excluded neonatal cases. The overall age-adjusted average annual rate was 5.3 hospitalizations/100,000 population. Highest risk was for adults >65 years of age, particularly men. Median length of hospitalization was 21 days; 22% of patients died during hospitalization. Median unadjusted associated cost for inpatient care was $46,684. Age-adjusted annual rates decreased during 2005-2012 for men (annual change -3.9%) and women (annual change -4.5%) and across nearly all age groups. We report a high mortality rate and decreasing incidence of hospitalizations for this disease.
侵袭性念珠菌病是美国一种主要的医院内真菌疾病，与高发病率和死亡率相关。我们分析了医疗成本和利用项目中的住院记录，以估计美国侵袭性念珠菌病相关住院的发病率。我们使用国际疾病分类第九版临床修订本中的编码，提取了2002年至2012年33个州的侵袭性念珠菌病数据；我们排除了新生儿病例。年龄调整后的总体年均发病率为每10万人中有5.3例住院。65岁以上成年人风险最高，尤其是男性。住院中位时长为21天；22%的患者在住院期间死亡。住院治疗未经调整的中位相关费用为46,684美元。2005年至2012年期间，男性（年变化率-3.9%）和女性（年变化率-4.5%）以及几乎所有年龄组的年龄调整后的年发病率均有所下降。我们报告了这种疾病的高死亡率和住院发病率的下降情况。
