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[利福平在成人及青少年毁损型肺结核联合治疗中应用的临床免疫学依据]

[Clinico-immunological substantiation of the use of rifampicin in the combined therapy of adults and adolescents with destructive pulmonary tuberculosis].

作者信息

Chernushenko E F, Kogosova L S, Il'nitskiĭ I G, Petrashenko A I, Goncharova S I

出版信息

Probl Tuberk. 1989(7):39-43.

PMID:2798385
Abstract

The effect of various doses of rifampicin on intensity of rosette formation was studied, and the immunological criteria for selective use of the drug in combined specific chemotherapy of extended destructive tuberculosis of the lungs were determined. It was shown that differential use of rifampicin with an account of its administration multiplicity and route promoted a decrease in the hospitalization terms and increased rate of discontinuation of tubercle bacilli isolation and cavern healing. The clinicoroentgenological findings were confirmed by the immunological tests characterizing various elements of the immunity system in patients.

摘要

研究了不同剂量利福平对玫瑰花结形成强度的影响,并确定了在肺部广泛性破坏性结核病联合特异性化疗中选择性使用该药物的免疫学标准。结果表明,考虑利福平的给药次数和途径进行差异化使用,可缩短住院时间,并提高结核杆菌分离停止率和空洞愈合率。临床X线检查结果得到了表征患者免疫系统各种元素的免疫学测试的证实。

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