Figueiredo Bárbara, Pinto Tiago Miguel, Pacheco Alexandra, Field Tiffany
School of Psychology, University of Minho, Campus de Gualtar, 4700-057 Braga, Portugal.
University of Miami Medical School, USA.
Biol Psychol. 2017 Feb;123:294-301. doi: 10.1016/j.biopsycho.2016.10.013. Epub 2016 Oct 29.
This study analyzed the mediating role of fetal heart rate variability (FHR) on prenatal depression and neonatal neurobehavioral maturity. A sample of 104 pregnant women was recruited and divided into two groups according to their Edinburgh Postnatal Depression Scale (EPDS) scores (depressed/non-depressed). FHR variability in response to speech stimuli was assessed at term (between 37 and 39 weeks gestation). The neonates were then assessed on the Neonatal Behavioral Assessment Scale (NBAS) during the first 5days after birth. The fetuses of non-depressed pregnant women showed higher HR variability than the fetuses of depressed pregnant women in response to speech stimuli, and later as neonates they performed more optimally on the NBAS (on autonomic stability and total scores). FHR variability mediated the relationship between the mother's prenatal depression and the neonatés NBAS performance. Prenatal depression effects on neonatal behavior may be partially explained by its adverse effects on fetal neurobehavioral maturity.
本研究分析了胎心率变异性（FHR）在产前抑郁与新生儿神经行为成熟度之间的中介作用。招募了104名孕妇样本，并根据她们的爱丁堡产后抑郁量表（EPDS）得分（抑郁/非抑郁）分为两组。在足月时（妊娠37至39周之间）评估对言语刺激的胎心率变异性。然后在出生后的前5天内，根据新生儿行为评估量表（NBAS）对新生儿进行评估。与抑郁孕妇的胎儿相比，非抑郁孕妇的胎儿在对言语刺激的反应中表现出更高的心率变异性，并且在出生后作为新生儿时，他们在NBAS（自主稳定性和总分）上的表现更优。胎心率变异性介导了母亲产前抑郁与新生儿NBAS表现之间的关系。产前抑郁对新生儿行为的影响可能部分是由其对胎儿神经行为成熟度的不利影响所解释的。
