Pinto Tiago Miguel, Caldas Filipa, Nogueira-Silva Cristina, Figueiredo Bárbara
Universidade do Minho, Escola de Psicologia, Braga, Portugal.
Universidade do Minho, Escola de Ciências da Saúde, Braga, Portugal.
J Pediatr (Rio J). 2017 Sep-Oct;93(5):452-459. doi: 10.1016/j.jped.2016.11.005. Epub 2017 Feb 20.
Maternal depression and anxiety have been found to negatively affect fetal and neonatal growth. However, the independent effects of maternal depression and anxiety on fetal-neonatal growth outcomes and trajectories remain unclear. This study aimed to analyze simultaneously the effects of maternal prenatal depression and anxiety on (1) neonatal growth outcomes, and (2), on fetal-neonatal growth trajectories, from the 2nd trimester of pregnancy to childbirth.
A sample of 172 women was recruited and completed self-reported measures of depression and anxiety during the 2nd and 3rd trimesters of pregnancy, and at childbirth. Fetal and neonatal biometrical data were collected from clinical reports at the same assessment moments.
Neonates of prenatally anxious mothers showed lower weight (p=0.006), length (p=0.025), and ponderal index (p=0.049) at birth than neonates of prenatally non-anxious mothers. Moreover, fetuses-neonates of high-anxiety mothers showed a lower increase of weight from the 2nd trimester of pregnancy to childbirth than fetuses-neonates of low-anxiety mothers (p<0.001). Considering maternal depression and anxiety simultaneously, only the effect of maternal anxiety was found on these markers of fetal-neonatal growth outcomes and trajectories.
This study demonstrates the independent longitudinal effect of maternal anxiety on major markers of fetal-neonatal growth outcomes and trajectories, simultaneously considering the effect of maternal depression and anxiety.
已发现母亲抑郁和焦虑会对胎儿及新生儿的生长产生负面影响。然而，母亲抑郁和焦虑对胎儿-新生儿生长结局及轨迹的独立影响仍不明确。本研究旨在同时分析母亲产前抑郁和焦虑对（1）新生儿生长结局，以及（2）从妊娠中期到分娩的胎儿-新生儿生长轨迹的影响。
招募了172名女性样本，她们在妊娠中期和晚期以及分娩时完成了抑郁和焦虑的自我报告测量。在相同评估时刻从临床报告中收集胎儿和新生儿的生物测量数据。
产前焦虑母亲的新生儿出生时体重（p = 0.006）、身长（p = 0.025）和 ponderal 指数（p = 0.049）低于产前非焦虑母亲的新生儿。此外，高焦虑母亲的胎儿-新生儿从妊娠中期到分娩时体重增加低于低焦虑母亲的胎儿-新生儿（p < 0.001）。同时考虑母亲抑郁和焦虑时，仅发现母亲焦虑对这些胎儿-新生儿生长结局和轨迹指标有影响。
本研究表明，在同时考虑母亲抑郁和焦虑影响的情况下，母亲焦虑对胎儿-新生儿生长结局和轨迹的主要指标具有独立的纵向影响。
