Cheng Jocelyn Y
Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Cogn Behav Neurol. 2016 Dec;29(4):212-216. doi: 10.1097/WNN.0000000000000109.
Musicogenic epilepsy is a rare syndrome in which music triggers seizures. Affective network processing appears to play a key role in epileptogenesis. Many people with epilepsy suffer from comorbid affective disorders, the shared basis of which involves similar pathophysiologies, including deficiencies of serotonergic and noradrenergic function. Seizures and mood disorders may thus have reciprocal effects on one another, particularly in emotionally precipitated syndromes such as musicogenic epilepsy. I report a man with long-standing depression and anxiety who developed focal epilepsy that evolved into musicogenic seizures. His case suggests a pathophysiologic basis for this shared phenomenon.
音乐源性癫痫是一种罕见的综合征，其中音乐可引发癫痫发作。情感网络处理似乎在癫痫发生过程中起关键作用。许多癫痫患者患有共病性情感障碍，其共同基础涉及相似的病理生理学，包括血清素能和去甲肾上腺素能功能缺陷。癫痫发作和情绪障碍可能因此相互产生影响，尤其是在如音乐源性癫痫这种由情绪诱发的综合征中。我报告了一名患有长期抑郁和焦虑的男性，他患上了局灶性癫痫，并演变成音乐源性癫痫发作。他的病例提示了这一共同现象的病理生理基础。
