老年大鼠中雌二醇对垂体多巴胺受体下调的损害。
Impaired down-regulation of pituitary dopamine receptors by estradiol in aged rats.
作者信息
Kochman K, Joseph J A, Blackman M R, Stagg C A, Roth G S
机构信息
Molecular Physiology and Genetics Section, Francis Scott Key Medical Center, Baltimore, Maryland 21224.
出版信息
Proc Soc Exp Biol Med. 1989 Oct;192(1):23-6. doi: 10.3181/00379727-192-42949.
Administration of 17 beta-estradiol to mature (6-12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24-25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.
对成熟（6 - 12个月）大鼠给予17β - 雌二醇，会使垂体多巴胺受体浓度降低超过50%，而不影响结合亲和力。相比之下，对衰老（24 - 25个月）大鼠进行相同操作时，受体浓度几乎没有变化。这些结果表明，雌激素刺激催乳素释放的年龄相关性增加并非由于受体水平多巴胺能抑制作用减弱。
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