Cabanac M, Ferber C, Fantino M
Université Laval, Faculté de Médecine, Ste-Foy, Québec, Canada.
Pharmacol Biochem Behav. 1989 Apr;32(4):1025-31. doi: 10.1016/0091-3057(89)90076-2.
An alimentary/thermic conflict of motivation was used to explore the effects of very low doses of dexfenfluramine (dFF), an anorectic serotoninergic agonist, on the parameters of food motivation, drive and incentive (or palatability). Six rats trained to feed 2 hr/day, were given the possibility to feed on chow in a shelter (25 degrees C), and to get a snack of shortcake, a highly palatable bait, from a feeder placed 16 m away in a very cold environment (-15 degrees C). dFF at 0.6 or 1.25 mg/kg decreased neither the chow intake in the shelter, nor the mean duration of the snacks in the cold, which is the parameter believed to be the best indicator of incentive. In contrast, dFF reduced the number of trips to the bait in the cold as well as the total mass of palatable bait ingested and the mean amount ingested by snack. Such an effect was no longer observed after a food restriction had reduced the body weight of the rats to 90% of its initial value. It is concluded that, even at doses too small to reduce the consumption of basic food, dFF decreases the drive to get palatable food.
采用动机性摄食/热量冲突来探究极低剂量的右芬氟拉明（dFF）（一种厌食性血清素能激动剂）对食物动机、驱力和诱因（或适口性）参数的影响。训练6只大鼠每天进食2小时，让它们有机会在一个遮蔽处（25摄氏度）进食食物，并从放置在非常寒冷环境（-15摄氏度）中16米远的喂食器中获取一块美味的零食——松饼。0.6或1.25毫克/千克的dFF既没有减少遮蔽处的食物摄入量，也没有减少在寒冷环境中吃零食的平均持续时间，而这一参数被认为是诱因的最佳指标。相比之下，dFF减少了在寒冷环境中前往诱饵处的次数、摄入的美味诱饵的总质量以及每次零食摄入的平均量。在食物限制使大鼠体重降至初始值的90%后，这种效应不再出现。得出的结论是，即使剂量小到不足以减少基本食物的消耗量，dFF也会降低获取美味食物的驱力。
