长期给予阿托品对小鼠运动能力及中枢神经系统乙酰胆碱水平的影响。
The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system.
作者信息
Molinengo L, Fundarò A, Orsetti M
机构信息
Institute of Pharmacology and Pharmacognosy, University of Turin, Torino, Italy.
出版信息
Pharmacol Biochem Behav. 1989 Apr;32(4):1075-7. doi: 10.1016/0091-3057(89)90085-3.
Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by acute atropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.
在以30、40和60毫克/千克/天的剂量慢性（20天）给予阿托品后，研究了小鼠的运动能力以及中枢神经系统皮质和皮质下乙酰胆碱水平的变化。观察到运动能力增加，类似于急性给予阿托品所诱导的情况，而急性给药导致的乙酰胆碱水平降低并未重现。这些结果表明，阿托品引起的小鼠运动能力变化与其对中枢神经系统中乙酰胆碱水平的改变无关。
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