Popović-Grle S, Pavlović M, Pavicić F, Rakusić N, Ivicević A
Plucne Bolesti. 1989 Jan-Jun;41(1-2):29-34.
The present paper deals with 16 patients who were referred to the Clinical Hospital for Lung Disease "Jordanovac", Zagreb. On admission they were supposed to have or had already been diagnosed to have bronchial asthma. Numerous data from the patients' history were evaluated as well as the results of allergy tests (skin tests, RIST, RAST, eosinophils in the blood and sputum) and parameters of the functional lung diagnostics (blood gas analysis during rest and exercise, spirometry, flow-volume, body plethysmography). It was established that allergy diagnostics is not carried out as required, even though it is necessary in all chronic obstructive lung diseases. Skin tests, inspite of the problems on the standardization of allergens and the average number of positive reactions in healthy volunteers, represent a significant diagnostic method for the determination of the role of allergic reaction in bronchial asthma. It is necessary to combine them with the determining level for specific IgE in serum (RAST), which would, if the other conditions are satisfactory, be a basis for specific immunotherapy. The value of skin tests is greater since a good correlation between them and bronchial sensibility was found established by specific broncho-provocative testing. The correlation between eosinophils in the blood and the sputum with allergic sensibilization in asthma was not confirmed in this work. For evaluation the localisation and degree of obstruction as well as the effect of therapy in asthma patients the best functional test was found to be the flow-volume.
本文研究了转诊至萨格勒布“约旦诺瓦茨”肺病临床医院的16例患者。入院时，他们被认为患有或已被诊断患有支气管哮喘。对患者病史中的大量数据以及过敏试验结果（皮肤试验、RIST、RAST、血液和痰液中的嗜酸性粒细胞）和肺功能诊断参数（静息和运动时的血气分析、肺量计、流量-容积、体容积描记法）进行了评估。结果表明，尽管在所有慢性阻塞性肺疾病中过敏诊断都是必要的，但并未按要求进行。皮肤试验尽管在变应原标准化和健康志愿者中阳性反应的平均数量方面存在问题，但仍是确定过敏反应在支气管哮喘中作用的重要诊断方法。有必要将其与血清中特异性IgE的测定水平（RAST）相结合，如果其他条件令人满意，这将成为特异性免疫治疗的基础。皮肤试验的价值更大，因为通过特异性支气管激发试验发现它们与支气管敏感性之间存在良好的相关性。在这项研究中，未证实血液和痰液中的嗜酸性粒细胞与哮喘中的过敏致敏之间的相关性。对于评估哮喘患者阻塞的部位和程度以及治疗效果，发现最佳的功能测试是流量-容积。
