Pesut D
Plucne Bolesti. 1989 Jan-Jun;41(1-2):35-8.
Recent studies indicate the significance of the hereditary predisposition in bronchogenic carcinoma occurrence. Beside epidemiologic, the paper presents referrential data indicating individual differences in genetically controlled sensitivity to carcinogenic activity from the exterior environment. The latest opinion on the possible role of AHH enzymes (aryl hydrocarbon hydroxylase) in the occurrence of malignant tumors of the respiratory organs has been presented. The results of HLA system investigations in patients with bronchogenic carcinoma, cytogenetic studies and latest investigations of activated oncogens have been presented as well.
近期研究表明遗传易感性在支气管癌发生中的重要性。除了流行病学方面，本文还提供了参考数据，表明个体在遗传控制下对外部环境致癌活性的敏感性存在差异。文中还介绍了关于芳烃羟化酶（AHH酶）在呼吸器官恶性肿瘤发生中可能作用的最新观点。此外，还展示了支气管癌患者的HLA系统研究结果、细胞遗传学研究以及激活癌基因的最新研究结果。
