Masaoka Hiroyuki, Gallus Silvano, Ito Hidemi, Watanabe Miki, Yokomizo Akira, Eto Masatoshi, Matsuo Keitaro
Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Nicotine Tob Res. 2017 Sep 1;19(9):1087-1094. doi: 10.1093/ntr/ntw316.
Smoking cessation has been known to be associated with drinking behaviors, which are influenced by polymorphisms in genes encoding alcohol metabolizing enzymes. The aim was to evaluate the impact of aldehyde dehydrogenase 2 (ALDH2, rs671) and alcohol dehydrogenase 1B (ADH1B, rs1229984) polymorphisms together with drinking behaviors on smoking cessation.
We conducted a cross-sectional study with 1137 former smokers and 1775 current smokers without any cancer at Aichi Cancer Center Hospital between 2001 and 2005. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for successful smoking cessation by comparing former smokers (quitters) with current smokers (non-quitters).
Older age, lower amount of cumulative smoking exposure, lower number of cigarettes per day, younger age of smoking initiation, shorter smoking duration, longer time to first cigarette in the morning, and lower amount of drinking among ever drinkers were predictors of smoking cessation. After careful adjustment for age, sex, smoking patterns, and drinking status, the ORs for smoking cessation among subjects with ALDH2 Glu/Lys and Lys/Lys were 1.02 (95% CI 0.84-1.23) and 1.78 (95% CI 1.23-2.58) compared with those with ALDH2 Glu/Glu, respectively Mediation analyses confirmed that the effect of ALDH2 Lys/Lys on smoking cessation was independent by dinking behaviors. No statistically significant association between ADH1B polymorphism and smoking cessation was observed.
In our Japanese population, ALDH2 polymorphism predicts smoking cessation, independent by drinking behaviors. Interventions for promoting smoking cessation by ALDH2 polymorphism may be useful in Asian populations.
We newly show that subjects with ALDH2 Lys/Lys genotype in a functional polymorphism, rs671, are more likely to quit smoking than those with ALDH2 Glu allele in a Japanese population. Our finding suggests that ALDH2 polymorphism may be useful for promoting smoking cessation in those specific populations as East Asian ones with frequent ALDH2 Lys allele carriers.
已知戒烟与饮酒行为有关，而饮酒行为受编码酒精代谢酶的基因多态性影响。本研究旨在评估乙醛脱氢酶2（ALDH2，rs671）和乙醇脱氢酶1B（ADH1B，rs1229984）基因多态性以及饮酒行为对戒烟的影响。
2001年至2005年间，我们在爱知癌症中心医院对1137名既往吸烟者和1775名无任何癌症的现吸烟者进行了一项横断面研究。通过比较既往吸烟者（戒烟者）和现吸烟者（未戒烟者），使用无条件逻辑回归模型估计成功戒烟的比值比（OR）和95%置信区间（CI）。
年龄较大、累积吸烟暴露量较低、每日吸烟支数较少、开始吸烟年龄较小、吸烟持续时间较短、早晨第一支烟时间较长以及既往饮酒者饮酒量较低是戒烟的预测因素。在对年龄、性别、吸烟模式和饮酒状况进行仔细调整后，与携带ALDH2 Glu/Glu的受试者相比，携带ALDH2 Glu/Lys和Lys/Lys的受试者戒烟的OR分别为1.02（95%CI 0.84 - 1.23）和1.78（95%CI 1.23 - 2.58）。中介分析证实，ALDH2 Lys/Lys对戒烟的影响不受饮酒行为的影响。未观察到ADH1B基因多态性与戒烟之间存在统计学显著关联。
在我们的日本人群中，ALDH2基因多态性可预测戒烟，且不受饮酒行为影响。通过ALDH2基因多态性促进戒烟的干预措施可能对亚洲人群有用。
我们首次表明，在日本人群中，功能性多态性rs671中携带ALDH2 Lys/Lys基因型的受试者比携带ALDH2 Glu等位基因的受试者更有可能戒烟。我们的研究结果表明，ALDH2基因多态性可能有助于在东亚等ALDH2 Lys等位基因携带者频繁的特定人群中促进戒烟。
