Mothersill C, Cusack A, Seymour C B
Saint Luke's Hospital, Rathgar, Dublin, Republic of Ireland.
Radiat Environ Biophys. 1989;28(3):203-12. doi: 10.1007/BF01211257.
A method which allows growth of normal human tissue to be studied in vitro is used to investigate possible interactive effects of radiation and environmentally important carcinogens on oesophageal and urothelial cell growth. Carcinogens chosen were selected for their known or suspected effect on the oesophageal mucosa or urothelium in vivo. The results indicate that with carcinogens alone concentrations can be identified that result in increased proliferation of cells. With radiation alone inhibition of cell proliferation occurs at all dose points examined. However, at precise combinations of radiation and carcinogen, greatly enhanced cell proliferation could be detected, suggesting a synergistic interaction between the two agents. The results may have implications for the design and interpretation of experiments aimed at elucidating early or premalignant changes in epithelial tissues and may indicate hitherto unsuspected interactions between radiation and environmentally important carcinogens.
一种用于研究正常人体组织体外生长的方法被用于调查辐射与对环境具有重要意义的致癌物对食管和尿路上皮细胞生长可能产生的相互作用。所选择的致癌物是因其在体内对食管黏膜或尿路上皮已知或疑似的作用而被挑选出来的。结果表明，单独使用致癌物时，可以确定导致细胞增殖增加的浓度。单独使用辐射时，在所检查的所有剂量点都会发生细胞增殖抑制。然而，在辐射与致癌物的精确组合下，可以检测到细胞增殖大大增强，这表明这两种因素之间存在协同相互作用。这些结果可能对旨在阐明上皮组织早期或癌前变化的实验设计和解释具有启示意义，并且可能表明辐射与对环境具有重要意义的致癌物之间迄今未被怀疑的相互作用。
