Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan; School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, Shaanxi Province, China.
Carbohydr Polym. 2017 Feb 10;157:429-437. doi: 10.1016/j.carbpol.2016.10.006. Epub 2016 Oct 5.
Recently, monoliths with continuous porous structure have received much attention for high-performance separation/adsorption matrix in biomedical and environmental fields. This study proposes a novel route to prepare cellulose monoliths with hierarchically porous structure by selecting cellulose acetate (CA) as the starting material. Thermally induced phase separation of CA solution using a mixed solvent affords a CA monolith, which is converted into the cellulose monolith by alkaline hydrolysis. Scanning electron microscopy images of the CA and cellulose monoliths reveal a continuous macropore with rough surface, and nitrogen adsorption/desorption analysis indicates the formation of a mesoporous structure. The macroporous structure could be controlled by changing the fabrication parameters. A series of reactive groups are introduced by chemical modifications on the surface of the cellulose monolith. The facile and diverse modifiability combined with its hydrophilic property make the hierarchically porous cellulose monolith a potential platform for use in separation, purification and bio-related applications.
最近，具有连续多孔结构的整体材料因其在生物医学和环境领域具有高性能分离/吸附基质而受到广泛关注。本研究提出了一种通过选择醋酸纤维素（CA）作为起始材料来制备具有分级多孔结构的纤维素整体材料的新途径。CA 溶液的热致相分离采用混合溶剂得到 CA 整体材料，然后通过碱水解将其转化为纤维素整体材料。CA 和纤维素整体材料的扫描电子显微镜图像显示出具有粗糙表面的连续大孔，氮气吸附/解吸分析表明形成了介孔结构。通过改变制备参数可以控制大孔结构。通过对纤维素整体材料表面进行化学修饰引入了一系列反应性基团。这种简便且多样化的可修饰性以及其亲水性使分级多孔纤维素整体材料成为分离、纯化和生物相关应用的潜在平台。
