Cao Yu, Han Wenjuan, Pu Ziyang, Wang Xiaofeng, Wang Bo, Liu Chuntai, Uyama Hiroshi, Shen Changyu
School of Materials Science & Engineering, Zhengzhou University Zhengzhou 450001 China
School of Mechanics and Engineering Science, National Center for International Research of Micro-Nano Molding Technology, Key Laboratory of Henan Province for Micro Molding Technology Zhengzhou 450001 China.
RSC Adv. 2020 Jul 13;10(44):26319-26325. doi: 10.1039/d0ra04687f. eCollection 2020 Jul 9.
Monoliths with a continuous porous structure are of great interest due to high transfer efficiency and large surface area in environmental and tissue engineering fields. This study demonstrated a facile method to prepare PCL monoliths with hierarchically porous structure by nonsolvent-thermally induced phase separation. A suitable mixed solvent mixture using ethanol as nonsolvent reduced the amount of dioxane and provided PCL monoliths with three levels of structures. The monolith structure was easily controlled by changing the fabrication parameters, such as the nonsolvent, the temperature of phase separation, the concentration of the PCL. Finally, the superhydrophilic monolith was easily obtained by polydopamine surface modification. The easy way of fabrication of a hierarchically porous PCL monolith with superhydrophilicity will find applications such as in tissue engineering and purification.
由于在环境和组织工程领域具有高传输效率和大表面积，具有连续多孔结构的整体材料备受关注。本研究展示了一种通过非溶剂热致相分离制备具有分级多孔结构的聚己内酯（PCL）整体材料的简便方法。使用乙醇作为非溶剂的合适混合溶剂混合物减少了二氧六环的用量，并为PCL整体材料提供了三级结构。通过改变制备参数，如非溶剂、相分离温度、PCL浓度，整体材料的结构很容易得到控制。最后，通过聚多巴胺表面改性很容易获得超亲水性整体材料。制备具有超亲水性的分级多孔PCL整体材料的简便方法将在组织工程和纯化等领域得到应用。
