Ortiz-Prieto Alejandro, Bernabeu-Wittel José, Zulueta-Dorado Teresa, Lorente-Lavirgen Ana I, Muñoz Miguel
Department of Dermatology, Virgen del Rocio University Hospital, Seville, Spain.
Department of Pathology, Virgen del Rocio University Hospital, Seville, Spain.
Arch Dermatol Res. 2017 Mar;309(2):97-102. doi: 10.1007/s00403-016-1707-y. Epub 2016 Dec 17.
The peptide substance P (SP) shows a widespread distribution in both the central and peripheral nervous systems, but it is also ubiquitous in the human body. After binding to the neurokinin-1 (NK-1) receptor, SP regulates tumoral angiogenesis and proliferation. Thus, knowledge of this system is the key for a better understanding and, hence, a better management of many human diseases, including vascular anomalies (VA). This study aims to examine the expression and localization of both SP and the NK-1 receptor in different vascular anomalies using an immunohistochemical technique. Our results demonstrated predominantly nuclear localization of SP in venous malformations and in one haemangioma sample, in contrast with cytoplasmic expression in capillary malformations and rapidly involuting congenital hemangioma (RICH). NK-1 receptor showed a cytoplasmic localization in all VA. In summary, all these findings demonstrate that SP and NK-1 receptor are expressed in VA, with different expression patterns depending on the nature of the anomaly, suggesting that they could play an important role in the pathogenesis of VA.
P物质（SP）肽在中枢和外周神经系统中广泛分布，但在人体中也普遍存在。与神经激肽-1（NK-1）受体结合后，SP可调节肿瘤血管生成和增殖。因此，了解该系统是更好地理解并进而更好地管理包括血管异常（VA）在内的许多人类疾病的关键。本研究旨在使用免疫组织化学技术检测不同血管异常中SP和NK-1受体的表达及定位。我们的结果显示，与毛细血管畸形和快速消退型先天性血管瘤（RICH）中的细胞质表达相反，SP在静脉畸形和一个血管瘤样本中主要定位于细胞核。NK-1受体在所有VA中均呈细胞质定位。总之，所有这些发现表明，SP和NK-1受体在VA中表达，且根据异常的性质呈现不同的表达模式，提示它们可能在VA的发病机制中发挥重要作用。
