物质 P 在癫痫中的调控。
Substance P Regulation in Epilepsy.
机构信息
The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin, China.
China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin, China.
出版信息
Curr Neuropharmacol. 2018;16(1):43-50. doi: 10.2174/1570159X15666170504122410.
BACKGROUND
Epilepsy is a common neurological disease characterized by abnormal temporary discharge of neurons in the central nervous system. In recent years, studies have revealed the localization and changes in the density of neuropeptides, such as substance P (SP) in the pathogenesis of epilepsy. This review is a concise overview of SP and their physiologic and pathologic functions on regulating epilepsy, and the underline mechanisms.
METHODS
We research and collect relative online content for reviewing the effects of SP in Epilepsy.
RESULTS
The SP/NK-1 receptor system may induce seizures and play an important role in status epilepticus and in experimental animal models of epilepsy. Newest studies show that several mechanisms may explain the excitatory effects of the SP/NK-1 receptor signaling pathway in epilepsy. By binding to the NK-1 receptor, NK-1 receptor antagonists may block the pathophysiological effects of SP, and further studies are needed to confirm the possible anti-epileptic activity of NK-1 receptor antagonists.
CONCLUSION
SP plays crucial roles on through binding with NK-1 receptor during epilepsy pathologic processing, and the NK-1 receptor is receiving a great attention as a therapeutic target for treating epilepsy. Thus, the use of NK-1 receptor antagonists for the treatment of epilepsy should be investigated in further studies.
背景
癫痫是一种常见的神经系统疾病，其特征是中枢神经系统神经元的异常短暂放电。近年来的研究揭示了神经肽（如 P 物质，SP）在癫痫发病机制中的定位和密度变化。本综述简要概述了 SP 及其调节癫痫的生理和病理功能，以及潜在的机制。
方法
我们研究并收集了相关的在线内容，以综述 SP 在癫痫中的作用。
结果
SP/NK-1 受体系统可能诱发癫痫发作，并在癫痫持续状态和实验性动物癫痫模型中发挥重要作用。最新研究表明，几种机制可能解释 SP/NK-1 受体信号通路在癫痫中的兴奋作用。通过与 NK-1 受体结合，NK-1 受体拮抗剂可能阻断 SP 的病理生理作用，进一步的研究需要证实 NK-1 受体拮抗剂可能具有抗癫痫活性。
结论
SP 通过与 NK-1 受体结合在癫痫病理过程中发挥关键作用，NK-1 受体作为治疗癫痫的治疗靶点受到了广泛关注。因此，应在进一步的研究中探讨 NK-1 受体拮抗剂用于治疗癫痫的可能性。
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