发育、干细胞与再生中的超转录
Hypertranscription in Development, Stem Cells, and Regeneration.
作者信息
Percharde Michelle, Bulut-Karslioglu Aydan, Ramalho-Santos Miguel
机构信息
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
出版信息
Dev Cell. 2017 Jan 9;40(1):9-21. doi: 10.1016/j.devcel.2016.11.010. Epub 2016 Dec 15.
Abstract
Cells can globally upregulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years but has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration, and cell competition. We review the history, methods for analysis, underlying mechanisms, and biological significance of hypertranscription.
摘要
细胞在特定转变过程中可全局上调其转录组，这种现象称为超转录。超转录的证据可追溯到70多年前，但在基因组学时代，直到最近它在很大程度上都被忽视了。我们讨论了支持超转录是胚胎发育、干细胞生物学、再生和细胞竞争中一个统一主题这一观点的数据。我们回顾了超转录的历史、分析方法、潜在机制和生物学意义。
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