名副其实：蛋白质合成促进胚胎干细胞的超转录。

Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells.

机构信息

Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

出版信息

Cell Stem Cell. 2018 Mar 1;22(3):281-282. doi: 10.1016/j.stem.2018.02.008.

DOI:10.1016/j.stem.2018.02.008

PMID:29499142

Abstract

The rapid proliferation and unlimited self-renewal of embryonic stem cells depends upon a permissive chromatin landscape that enables hypertranscription. In this issue of Cell Stem Cell, Bulut-Karslioglu et al. report that euchromatin and transcriptional output are enhanced by protein synthesis in embryonic stem cells (Bulut-Karslioglu et al., 2018).

摘要

胚胎干细胞的快速增殖和无限自我更新依赖于一种允许过度转录的许可染色质景观。在本期《细胞-干细胞》杂志上，Bulut-Karslioglu 等人报道了蛋白质合成在胚胎干细胞中增强了常染色质和转录产物（Bulut-Karslioglu 等人，2018）。