Kolovou Vana, Marvaki Apostolia, Boutsikou Maria, Vasilopoulos Georgios, Degiannis Dimitrios, Marvaki Christina, Kolovou Genovefa
Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Open Cardiovasc Med J. 2016 Nov 21;10:233-239. doi: 10.2174/1874192401610010233. eCollection 2016.
The present study is on line with our previous studies evaluating the influence of ATP-binding cassette transporter A1 () gene polymorphisms on the lipid variables of Greek student-nurses. The current study was undertaken to (1) estimate the influence of variant(s) such as rs2066715 (V825I), R219K, R1587K, I883M of gene on lipid variables and (2) evaluate the effect of all four polymorphisms on common demographic parameters.
The study population involved 432 unrelated nurses (86 men) who were genotyped for polymorphisms and correlated according to lipid variables [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] and demographic parameters (age, gender, BMI, waist circumference).
According to lipid variables concentration there was no difference between genotypes and alleles of V825I, R219K and I883M polymorphisms. The LDL-C concentration was 13% lower in RR compared with RK genotype (100.7 . 113.9 mg/dl, p=0.013) of R1587K gene polymorphism. In regression analysis the effects of age, gender and only R1587K gene polymorphism on LDL-C concentrations were proved significant. Additionally, LDL-C was increased (by 1.29 mg/dl on average) by every year of increase of age. Moreover, females had lower LDL-C concentrations as compared with males.
Findings suggested that only R1587K polymorphism of gene was associated with lipid variables, age, and gender of Greek nurses. These findings may be helpful in assessing the risk factors for premature coronary heart disease and distinct individuals with lower/higher atherosclerotic burden.
本研究与我们之前评估三磷酸腺苷结合盒转运蛋白A1（ABCA1）基因多态性对希腊学生护士血脂变量影响的研究一致。当前研究旨在：（1）评估ABCA1基因的rs2066715（V825I）、R219K、R1587K、I883M等变体对血脂变量的影响；（2）评估所有四种ABCA1多态性对常见人口统计学参数的影响。
研究人群包括432名无亲属关系的护士（86名男性），对其进行ABCA1多态性基因分型，并根据血脂变量[总胆固醇（TC）、甘油三酯（TGs）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和载脂蛋白（apo）A]以及人口统计学参数（年龄、性别、体重指数、腰围）进行相关性分析。
根据血脂变量浓度，V825I基因多态性、R219K基因多态性和I883M基因多态性的基因型和等位基因之间没有差异。R1587K基因多态性的RR基因型与RK基因型相比，LDL-C浓度低13%（100.7±113.9mg/dl，p=0.013）。回归分析表明，年龄、性别以及仅R1587K基因多态性对LDL-C浓度的影响具有显著性。此外，年龄每增加一岁，LDL-C平均升高（1.29mg/dl）。而且，女性的LDL-C浓度低于男性。
研究结果表明，ABCA1基因仅R1587K多态性与希腊护士的血脂变量、年龄和性别相关。这些发现可能有助于评估早发性冠心病的危险因素，并区分动脉粥样硬化负担较低/较高的个体。
