通过硅杂环丁烷的串联去对称化/分子间脱氢硅氢化反应构建手性四有机硅
Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation.
机构信息
School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
出版信息
Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1125-1129. doi: 10.1002/anie.201609022. Epub 2016 Dec 19.
PMID:27990736
Abstract
We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization-dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee. Chiral TMS-segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.
摘要
我们报告了一种通过串联硅杂环丁烷（SCB）去对称化-脱氢硅烷化来构建手性四有机硅的方法。通过该方法获得了一系列具有手性季硅中心的二苯并硅杂环戊烯，产率高，对映选择性高达 93%ee。手性 TMS-segphos 配体在反应活性和对映选择性方面表现出优越性。
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