Taylor G, Thomas L H, Stott E J
AFRC Institute for Animal Health, Compton Laboratory, Berkshire.
Res Vet Sci. 1989 Sep;47(2):231-5.
The inflammatory response in the air-passages of the lungs of calves after intranasal inoculation with respiratory syncytial virus (RSV) was compared in RSV-vaccinated and control animals. Total cells recovered from lung washings remained the same; however, the fold by eight days after infection and the type of cells changed from a predominance (85 per cent) of macrophages to equal proportions of macrophages and neutrophils (45 per cent) during the course of infection. The absolute numbers of neutrophils rose by 15-fold. In contrast, when RSV-vaccinated calves were challenged, the total number of cells recovered from lung washings remained the same; however, the numbers of macrophages decreased and the numbers of neutrophils increased by fivefold. Cytological studies of the lung washings revealed no evidence of an exacerbated inflammatory response in RSV-vaccinated calves. Levels of virus replication were significantly reduced in RSV-vaccinated compared with control animals.
对经鼻接种呼吸道合胞病毒（RSV）的犊牛，比较了接种RSV疫苗的动物和对照动物肺部气道的炎症反应。从肺灌洗中回收的总细胞数保持不变；然而，感染后8天时细胞数量增加倍数以及细胞类型从以巨噬细胞为主（85%）转变为感染过程中巨噬细胞和中性粒细胞比例相等（各占45%）。中性粒细胞的绝对数量增加了15倍。相比之下，对接种RSV疫苗的犊牛进行攻毒时，从肺灌洗中回收的细胞总数保持不变；然而，巨噬细胞数量减少，中性粒细胞数量增加了五倍。肺灌洗的细胞学研究未发现接种RSV疫苗的犊牛有炎症反应加剧的证据。与对照动物相比，接种RSV疫苗的动物病毒复制水平显著降低。
