Chouchoulis Konstantinos, Chiladakis John, Koutsogiannis Nikolaos, Davlouros Periklis, Kaza Maria, Alexopoulos Dimitrios
Cardiology Department, University Hospital of Patras, Rion, Patras, Greece.
School of Medicine, University of Patras, Rion, Patras, Greece.
Future Cardiol. 2017 Jan;13(1):13-22. doi: 10.2217/fca-2016-0052. Epub 2016 Dec 19.
We assessed whether antiarrhythmic drug-induced QT interval prolongation affects left ventricular function.
Study population included 54 patients with symptomatic recent onset atrial fibrillation spontaneously cardioverted to sinus rhythm. Electrocardiographic and echocardiographic studies were done before initiating and after achieving drug's steady state.
Significantly prolonged corrected QT interval (QTc) was noticed following only sotalol and amiodarone. The corrected precontraction time increased after sotalol (p = 0.005) and amiodarone (p = 0.017), not propafenone (p = 0.139). Analysis results between ΔEF and ΔQTc, ΔEF and ΔQTc(p), ΔE/e' and ΔQTc, ΔE/e' and ΔQTc(p) for amiodarone group were (p = 0.66, p = 0.20, p = 0.66, p = 0.33), for sotalol (p = 0.36, p = 0.51, p = 0.44, p = 0.33) and for propafenone (p = 0.38, p = 0.12, p = 0.89, p = 0.61), respectively.
QT interval prolongation following antiarrhythmic therapy does not affect significantly left ventricular function.
