Hinney Barbara, Wiedermann Sandra, Kaiser Waltraud, Krücken Jürgen, Joachim Anja
Department of Pathobiology, Institute of Parasitology, Vetmeduni Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Tierärztliche Praxisgemeinschaft Passail OG, 8162 Passail, Austria.
Pathogens. 2022 Apr 21;11(5):498. doi: 10.3390/pathogens11050498.
Anthelmintic resistance (AR) of trichostrongyloids is widespread in Europe, but there is no up-to-date information on the spread of AR in caprine parasites in Austria. Eprinomectin (EPR) is currently the only anthelmintic drug of the macrocyclic lactones registered for goats in Europe. The aim of the present study was to gather information regarding the efficacy of anthelmintics against trichostrongyloids on a dairy goat farm in Austria with reported treatment failure of macrocyclic lactones and to determine the presence of different trichostrongyloid genera. Faecal egg count reduction tests (FECRT) using Mini-FLOTAC were performed with eprinomectin (EPR) and moxidectin (MOX). Egg count reduction, calculated with the R package egg-Counts, was 44% for EPR and 86% for MOX, confirming AR of trichostrongyloids for both compounds. The most frequently detected genus in larval cultures was followed by . This is the first report of MOX resistance in caprine trichostrongyloids in Europe. Failure of EPR and MOX to control trichostrongyloid infections is a severe threat to dairy goat farming, since other compounds must not be applied in goats used for milk production. is one of the most pathogenic parasites of small ruminants and can quickly develop AR. Thus, immediate action should be taken to slow the further spread of AR in this and other roundworm species of ruminants in Austria.
毛圆线虫的抗蠕虫药耐药性在欧洲广泛存在，但奥地利尚无关于山羊寄生虫中耐药性传播的最新信息。埃普利诺菌素（EPR）是目前欧洲唯一注册用于山羊的大环内酯类抗蠕虫药。本研究的目的是收集奥地利一个奶山羊场中抗蠕虫药对毛圆线虫的疗效信息，该场曾报告大环内酯类药物治疗失败，并确定不同毛圆线虫属的存在情况。使用Mini-FLOTAC进行了粪便虫卵计数减少试验（FECRT），分别使用了埃普利诺菌素（EPR）和莫昔克丁（MOX）。用R包egg-Counts计算得出，EPR的虫卵计数减少率为44%，MOX为86%，证实这两种化合物对毛圆线虫均存在耐药性。幼虫培养中最常检测到的属是 ，其次是 。这是欧洲山羊毛圆线虫对MOX耐药性的首次报告。EPR和MOX无法控制毛圆线虫感染对奶山羊养殖构成严重威胁，因为其他化合物不得用于产奶山羊。 是小型反刍动物最具致病性的寄生虫之一，且能迅速产生耐药性。因此，应立即采取行动，减缓奥地利这种寄生虫及其他反刍动物圆虫耐药性的进一步传播。
