Graeve Catherine, McGovern Patricia M, Arnold Susan, Polovich Martha
University of Minnesota.
Georgia State University.
Oncol Nurs Forum. 2017 Jan 1;44(1):E10-E19. doi: 10.1188/17.ONF.E10-E19.
PURPOSE/OBJECTIVES: To develop and test a worksite intervention that protects healthcare workers who handle antineoplastic drugs from work-related exposures. .
DESIGN: Intervention study. .
SETTING: A university hospital in a large midwestern metropolitan area and its outpatient chemotherapy infusion clinic. .
SAMPLE: 163 staff (nurses, pharmacists, and pharmacy technicians) who work with antineoplastic agents. .
METHODS: A self-report survey measured workplace and individual factors to assess use of personal protective equipment (PPE). Wipe samples were tested for surface contamination. An intervention incorporating study findings and worker input was developed. .
MAIN RESEARCH VARIABLES: PPE use was the dependent variable, and the independent variables included knowledge of the hazard, perceived risk, perceived barriers, interpersonal influence, self-efficacy, conflict of interest, and workplace safety climate. .
FINDINGS: PPE use was lower than recommended and improved slightly postintervention. Self-efficacy and perceived risk increased on the post-test survey. Chemical residue was found in several areas. Awareness of safe-handling precautions improved postintervention. The unit where nurses worked was an important predictor of safety climate and PPE use on the pretest but less so following the intervention. .
CONCLUSIONS: Involving staff in developing an intervention for safety ensures that changes made will be feasible. Units that implemented workflow changes had decreased contamination. .
Worksite analysis identifies specific targets for interventions to improve antineoplastic drug handling safety.
目的/目标：开发并测试一种工作场所干预措施，以保护处理抗肿瘤药物的医护人员免受与工作相关的暴露。
干预研究。
中西部一个大城市的一家大学医院及其门诊化疗输液诊所。
163名使用抗肿瘤药物的工作人员（护士、药剂师和药房技术员）。
通过一份自我报告调查问卷来测量工作场所和个人因素，以评估个人防护装备（PPE）的使用情况。擦拭样本用于检测表面污染。根据研究结果和工作人员的意见制定了一项干预措施。
PPE的使用是因变量，自变量包括对危害的认知、感知风险、感知障碍、人际影响、自我效能感、利益冲突和工作场所安全氛围。
PPE的使用低于推荐水平，干预后略有改善。在后测调查问卷中，自我效能感和感知风险有所增加。在几个区域发现了化学残留物。干预后，对安全操作预防措施的认识有所提高。护士工作的科室在干预前是安全氛围和PPE使用的重要预测因素，但干预后作用减弱。
让工作人员参与安全干预措施的制定可确保所做的改变切实可行。实施工作流程改变的科室污染有所减少。
工作场所分析确定了改善抗肿瘤药物处理安全性干预措施的具体目标。
