Alessi Helena, Dutra Lívia Almeida, Braga Pedro, Pedroso José Luiz, Toso Fabio F, Kayser Cristiane, Barsottini Orlando G P
Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
Universidade Estadual do Ceará, Centro de Ciências da Saúde, Fortaleza CE, Brasil.
Arq Neuropsiquiatr. 2016 Dec;74(12):1021-1030. doi: 10.1590/0004-282X20160150.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Neurological manifestations are associated with impaired quality of life, and high morbidity and mortality rates. Nineteen neuropsychiatric syndromes have been identified associated with SLE, and can be divided into central and peripheral manifestations. This article reviews major neuropsychiatric manifestations in patients with SLE and discusses their clinical features, radiological findings and treatment options.
系统性红斑狼疮（SLE）是一种累及多个器官的慢性自身免疫性疾病，其特征为自身抗体的产生和组织损伤的发展。SLE的病因部分已知，涉及多种遗传和环境因素。多达50%的SLE患者在病程中会出现神经受累。神经表现与生活质量受损以及高发病率和死亡率相关。已确定19种神经精神综合征与SLE相关，可分为中枢和外周表现。本文综述了SLE患者的主要神经精神表现，并讨论了它们的临床特征、影像学表现和治疗选择。
