Pelouze G A
Unité de Chirurgie Thoracique et Cardio-Vasculaire, Clinique Larrieu, Pau.
Rev Neurol (Paris). 1989;145(6-7):478-81.
Atheromatous plaques of the vertebral artery ostium are usually smooth and cause hemodynamic ischemia in the vertebro-basilar territory only when stenosis is severe. A case of crescendo vertebro-basilar attacks is reported and related to an ulcerated plaque of the vertebral artery ostium. The patient underwent surgical endarterectomy after failure of an antiplatelet treatment. He has remained asymptomatic for six months. Diagnosis of vertebral artery ulceration is difficult by ultrasonics or digitalized arteriography because of the small diameter of the vessel and its posterior origin. The frequency of ulcerated plaques of the subclavio-vertebral intersection is probably underestimated in the literature Labauge et al. (1987) emphasized recently the risk of cerebellar infarction during the natural history of vertebral artery occlusion. Crescendo vertebro-basilar transient ischemic attacks can be caused by a plaque rupture of of the vertebral ostium which leads secondarily to vertebral artery occlusion. Therapeutic options for atheromatous lesions of the posterior circulation are not clearly defined by controlled studies. In the reported case and in series reported in the literature, surgery would appear to be an efficient procedure with low mortality and morbidity.
椎动脉开口处的动脉粥样硬化斑块通常较为光滑,只有在狭窄严重时才会导致椎基底动脉供血区域的血流动力学性缺血。本文报告了一例进行性椎基底动脉发作的病例,其与椎动脉开口处的溃疡性斑块有关。该患者在抗血小板治疗失败后接受了外科动脉内膜切除术。他已保持无症状状态六个月。由于椎动脉直径较小且起源于后方,通过超声或数字化血管造影很难诊断椎动脉溃疡。锁骨下 - 椎动脉交汇处溃疡性斑块的发生率在文献中可能被低估。拉博热等人(1987年)最近强调了椎动脉闭塞自然病程中发生小脑梗死的风险。进行性椎基底动脉短暂性脑缺血发作可能由椎动脉开口处的斑块破裂引起,继而导致椎动脉闭塞。后循环动脉粥样硬化病变的治疗选择尚未通过对照研究明确界定。在本文报告的病例以及文献中报道的系列病例中,手术似乎是一种死亡率和发病率较低的有效治疗方法。