Leuthardt R, Trümpi B, Morger R
Ostschweizerisches Kinderspital, Klinik für Kinderchirurgie, St. Gallen.
Schweiz Med Wochenschr. 1989 Oct 7;119(40):1372-4.
In 22 children serum levels and concentration of erythromycin in the tonsil tissue after intravenous injection were measured. The concentration of erythromycin in the tonsils one hour after injection was four times the serum level. Two hours after injection the ratio was reduced significantly to 1.2. From the results it is concluded that perioperative antibiotic therapy with erythromycin has pharmacodynamic advantages.
对22名儿童静脉注射红霉素后，检测其血清水平及扁桃体组织中红霉素的浓度。注射后1小时扁桃体中红霉素的浓度是血清水平的4倍。注射后2小时，该比例显著降至1.2。从结果得出结论，围手术期使用红霉素进行抗生素治疗具有药效学优势。
