Galioto G B, Mevio E, Galioto P, Zanuso G, Lepore A M
Otorhinolaryngologic Clinic, University of Pavia, Italy.
Int J Clin Pharmacol Ther Toxicol. 1989 Mar;27(3):126-8.
The concentrations of flurithromycin in serum and palatine tonsils of eleven adult male patients undergoing tonsillectomy were determined. Each patient received 500 mg t.i.d., in all ten doses, before tonsillectomy. Flurithromycin concentrations were measured by a microbiological method. Mean serum levels (+/- SE) were 0.72 microgram/ml (+/- 0.19) after 8 h from the 9th dose and 0.67 microgram/ml (+/- 0.13) after 4 h from the 10th dose. Average concentrations (+/- SE) in tonsils were: 1.43 +/- 0.20 microgram/g (right) and 1.32 +/- 0.21 (left) 4 h after the last administration. Therefore, the mean tissue/serum ratio was about 2:1. These results indicate a good diffusion of flurithromycin from serum to tonsillar tissue.
测定了11例接受扁桃体切除术的成年男性患者血清和腭扁桃体中氟红霉素的浓度。每位患者在扁桃体切除术前接受500mg，每日三次，共十剂。采用微生物学方法测定氟红霉素浓度。第9剂给药8小时后血清平均水平（±标准误）为0.72微克/毫升（±0.19），第10剂给药4小时后为0.67微克/毫升（±0.13）。末次给药4小时后扁桃体中的平均浓度（±标准误）为：右侧1.43±0.20微克/克，左侧1.32±0.21微克/克。因此，平均组织/血清比值约为2:1。这些结果表明氟红霉素从血清到扁桃体组织的扩散良好。
