School of Public Health, Seoul National University, Seoul 08826, Republic of Korea; Taean Environmental Health Center, Taean 32148, Republic of Korea.
School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Sci Total Environ. 2017 Feb 15;580:946-952. doi: 10.1016/j.scitotenv.2016.12.044. Epub 2016 Dec 16.
In December 2007, the Hebei Spirit oil spill occurred on the west coast of South Korea. Association between crude oil exposure and the levels of urinary oxidative stress biomarkers was reported among the local residents, 1.5years after the accident. The aim of this study was to follow-up possible longer-term effects of the oil spill among the residents near the oil spill. Six years after the accident, urinary oxidative stress biomarkers of the residents were associated with surrogates of oil exposure. The target subjects were divided into two groups based on the distance of their residence to the spill site, i.e., those near the spill site ('Near' group, n=476), and those far from the spill ('Far' group, n=152). A questionnaire was administered by trained interviewers or self-reporting, and demographic information and other parameters of the participants, such as socioeconomic status, smoking and drinking behaviors, disease history, and duration of clean-up activities after the spill, were collected. The participants' levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) in 12 h urine samples were measured as indicators of oxidative DNA damage and lipid peroxidation, respectively. A general linear model was used for statistical analysis. Urinary MDA and 8-OHdG levels measured from 'Near' group, i.e., geometric mean of 2.19μmol/g creatinine, and 5.41μg/g creatinine, respectively, were higher than those of 'Far' group. Especially, urinary 8-OHdG levels in the 'Near' group were significantly higher than those of 'Far' after adjusting relevant covariates. In addition, the duration of clean-up activities showed a significant association with both urinary 8-OHdG and MDA levels. Even 6years after the oil spill, positive associations between oxidative stress biomarkers and surrogates of oil exposure were evident. While the present study design lacks biomarkers of exposure, the results of this study suggest that the consequences of oil pollution may last for years.
2007 年 12 月，韩国西海岸发生河北精神号油轮泄漏事件。据报道，事故发生 1.5 年后，当地居民的尿液氧化应激生物标志物水平与原油暴露水平之间存在关联。本研究的目的是在事故发生后，对附近居民进行长期的油污染影响的跟踪调查。事故发生 6 年后，居民的尿液氧化应激生物标志物与石油暴露的替代物有关。以居民居住距离泄漏点的远近为依据，将目标人群分为两组，即靠近泄漏点的（“近”组，n=476）和远离泄漏点的（“远”组，n=152）。通过受过培训的访谈者或自我报告的方式进行问卷调查，并收集参与者的人口统计学信息和其他参数，如社会经济地位、吸烟和饮酒行为、疾病史以及事故发生后清理活动的持续时间。测量参与者 12 小时尿液样本中的 8-羟基-2-脱氧鸟苷（8-OHdG）和丙二醛（MDA）水平，分别作为氧化 DNA 损伤和脂质过氧化的指标。采用一般线性模型进行统计分析。“近”组的尿液 MDA 和 8-OHdG 水平分别为 2.19μmol/g 肌酐和 5.41μg/g 肌酐，均高于“远”组。特别是，在调整了相关协变量后，“近”组的尿液 8-OHdG 水平明显高于“远”组。此外，清理活动的持续时间与尿液 8-OHdG 和 MDA 水平均呈显著相关。即使在油轮泄漏 6 年后，氧化应激生物标志物与石油暴露替代物之间仍存在明显的关联。虽然本研究设计缺乏暴露生物标志物，但本研究结果表明，石油污染的后果可能会持续多年。
