生长激素释放肽在脑部疾病中的神经作用：超越代谢功能。
The neurological effects of ghrelin in brain diseases: Beyond metabolic functions.
机构信息
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, China.
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.
出版信息
Neurosci Biobehav Rev. 2017 Feb;73:98-111. doi: 10.1016/j.neubiorev.2016.12.010. Epub 2016 Dec 16.
Ghrelin, a peptide released by the stomach that plays a major role in regulating energy metabolism, has recently been shown to have effects on neurobiological behaviors. Ghrelin enhances neuronal survival by reducing apoptosis, alleviating inflammation and oxidative stress, and accordingly improving mitochondrial function. Ghrelin also stimulates the proliferation, differentiation and migration of neural stem/progenitor cells (NS/PCs). Additionally, the ghrelin is benefit for the recovery of memory, mood and cognitive dysfunction after stroke or traumatic brain injury. Because of its neuroprotective and neurogenic roles, ghrelin may be used as a therapeutic agent in the brain to combat neurodegenerative disease. In this review, we highlight the pre-clinical evidence and the proposed mechanisms underlying the role of ghrelin in physiological and pathological brain function.
胃泌素，一种由胃释放的肽，在调节能量代谢中起主要作用，最近被证明对神经生物学行为有影响。胃泌素通过减少细胞凋亡、减轻炎症和氧化应激，从而改善线粒体功能，促进神经元存活。胃泌素还刺激神经干细胞/祖细胞（NS/PCs）的增殖、分化和迁移。此外，胃泌素有利于中风或创伤性脑损伤后记忆、情绪和认知功能障碍的恢复。由于其神经保护和神经发生作用，胃泌素可用作大脑中的治疗剂，以对抗神经退行性疾病。在这篇综述中，我们强调了胃泌素在生理和病理性脑功能中的作用的临床前证据和提出的机制。
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