Bi Mingxia, Liu Chang, Wang Yulin, Liu Shuang-Jiang
State Key Laboratory of Microbial Biotechnology, Shandong University, Qingdao 266237, China.
State Key Laboratory of Microbial Resources and Environmental Microbiology Research Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Microorganisms. 2023 Jun 8;11(6):1527. doi: 10.3390/microorganisms11061527.
Increasing clinical and preclinical evidence implicates gut microbiome (GM) dysbiosis as a key susceptibility factor for neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). In recent years, neurodegenerative diseases have been viewed as being driven not solely by defects in the brain, and the role of GM in modulating central nervous system function via the gut-brain axis has attracted considerable interest. Encouraged by current GM research, the development of new probiotics may lead to tangible impacts on the treatment of neurodegenerative disorders. This review summarizes current understandings of GM composition and characteristics associated with neurodegenerative diseases and research demonstrations of key molecules from the GM that affect neurodegeneration. Furthermore, applications of new probiotics, such as , , , and , for the remediation of neurodegenerative diseases are discussed.
越来越多的临床和临床前证据表明，肠道微生物群（GM）失调是包括阿尔茨海默病（AD）和帕金森病（PD）在内的神经退行性疾病的关键易感因素。近年来，神经退行性疾病不再被认为仅仅是由大脑缺陷驱动的，GM通过肠-脑轴调节中枢神经系统功能的作用引起了相当大的兴趣。受当前GM研究的鼓舞，新型益生菌的开发可能会对神经退行性疾病的治疗产生切实影响。本综述总结了目前对与神经退行性疾病相关的GM组成和特征的理解，以及GM中影响神经退行性变的关键分子的研究证明。此外，还讨论了新型益生菌，如 、 、 和 ，在神经退行性疾病治疗中的应用。
