Sanatorium Kilchberg, Centre for Stress Related Illnesses, Alte Landstrasse 70, 8802, Kilchberg, Switzerland; University Hospital of Psychiatry and Psychotherapy, Translational Research Center, Bolligenstrasse 111, 3000 Bern 60, Switzerland.
University Hospital of Psychiatry and Psychotherapy, Translational Research Center, Bolligenstrasse 111, 3000 Bern 60, Switzerland.
Neurosci Biobehav Rev. 2017 Feb;73:112-122. doi: 10.1016/j.neubiorev.2016.12.005. Epub 2016 Dec 16.
To compare and contrast burnout and depression is not only a conceptual issue, but may deliver important directions for treatment approaches and stabilize the awareness of disease which is essential for affected individuals. Because of the symptomatic overlap, it is a subject of multidimensional research and discussion to find specific signatures to differentiate between the two phenomena or to present evidence that they are different aspects of the same disorder. Both pathologies are regarded as stress-related disorders. Therefore, in this review burnout and depression are discussed on the basis of biological parameters, mainly heart rate variability (HRV) and brain-derived neurotrophic factor (BDNF), which are crucial to the stress response system. It emerges that instead of finding one specific discriminating marker, future research should rather concentrate on elaborating indices for burnout and depression which integrate combinations of parameters found in genetics, neurobiology, physiology and environment.
将倦怠和抑郁进行比较和对比不仅是一个概念问题，而且可能为治疗方法提供重要的指导方向，并稳定对疾病的认识，这对受影响的个人至关重要。由于症状重叠，因此，寻找区分这两种现象的特定特征，或者提出证据表明它们是同一疾病的不同方面，是多维研究和讨论的主题。这两种病理都被认为是与压力相关的疾病。因此，在这篇综述中，基于生物参数（主要是心率变异性（HRV）和脑源性神经营养因子（BDNF））讨论了倦怠和抑郁，这些参数对压力反应系统至关重要。结果表明，未来的研究不应寻找一个特定的鉴别标志物，而应集中精力制定倦怠和抑郁的指标，这些指标将整合遗传学、神经生物学、生理学和环境中发现的参数组合。
