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史蒂文斯-约翰逊综合征患者波士顿人工角膜眼内炎

Endophthalmitis in Boston Keratoprosthesis in a Patient with Steven-Johnson Syndrome.

作者信息

Al-Otaibi Humoud M, Talea Mohammed, Kirat Omar, Stone Donald U, May William N, Kozak Igor

机构信息

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.

出版信息

Middle East Afr J Ophthalmol. 2016 Oct-Dec;23(4):329-331. doi: 10.4103/0974-9233.194095.

DOI:10.4103/0974-9233.194095
PMID:27994401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5141631/
Abstract

A 25-year-old Syrian male with a previous episode of Stevens-Johnson syndrome with bilateral corneal cicatrization previously underwent surgery for Type 1 Boston Keratoprosthesis (K-Pro). Sixteen months after the K-Pro surgery, the patient presented with decreased vision to hand motion and microbial keratitis of the graft around the K-Pro with purulent discharge. Corneal scrapings were nonrevealing. B-scan in 3 days showed increased debris in the vitreous cavity and thickened retinochoroidal layer. Intravitreal tap and injections of vancomycin and ceftazidime were performed. The vitreous culture revealed β-hemolytic ; fungal cultures were negative. Repeat B-scan 3 days later demonstrated decreased vitreous opacity, and the patient felt more comfortable and was without pain. His visual acuity improved to 20/70, ocular findings have been stable for 9 months, and the patient continues to be monitored.

摘要

一名25岁的叙利亚男性,曾患史蒂文斯-约翰逊综合征并伴有双侧角膜瘢痕形成,此前接受了1型波士顿人工角膜(K-Pro)植入手术。K-Pro手术后16个月,患者出现视力下降至仅能感知手动,且人工角膜周围的移植片发生微生物性角膜炎并伴有脓性分泌物。角膜刮片检查未发现异常。3天后的B超显示玻璃体腔碎屑增多,视网膜脉络膜层增厚。进行了玻璃体穿刺并注射万古霉素和头孢他啶。玻璃体培养显示β-溶血性;真菌培养为阴性。3天后复查B超显示玻璃体混浊减轻,患者感觉更舒适且无疼痛。其视力提高到20/70,眼部情况已稳定9个月,患者仍在继续接受监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3955/5141631/f3966a353802/MEAJO-23-329-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3955/5141631/fd3f4a3b527d/MEAJO-23-329-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3955/5141631/f3966a353802/MEAJO-23-329-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3955/5141631/fd3f4a3b527d/MEAJO-23-329-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3955/5141631/f3966a353802/MEAJO-23-329-g002.jpg

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本文引用的文献

1
Review of endophthalmitis following Boston keratoprosthesis type 1.Boston 角膜型 1 术后眼内炎的回顾。
Br J Ophthalmol. 2012 Jun;96(6):776-80. doi: 10.1136/bjophthalmol-2011-301263. Epub 2012 Apr 4.
2
Microbiota evaluation of patients with a Boston type I keratoprosthesis treated with topical 0.5% moxifloxacin and 5% povidone-iodine.对接受局部使用 0.5%莫西沙星和 5%聚维酮碘治疗的波士顿 I 型角膜假体患者的微生物组评估。
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Infectious endophthalmitis after Boston type 1 keratoprosthesis implantation.
波士顿 1 型角膜假体植入术后感染性眼内炎。
Cornea. 2012 Apr;31(4):346-9. doi: 10.1097/ICO.0b013e31821eea2f.
4
Infectious endophthalmitis in adult eyes receiving Boston type I keratoprosthesis.成人 Boston Ⅰ型角膜移植术后眼感染性眼内炎。
Ophthalmology. 2012 Apr;119(4):674-81. doi: 10.1016/j.ophtha.2011.10.009. Epub 2012 Jan 23.
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Longer-term vision outcomes and complications with the Boston type 1 keratoprosthesis at the University of California, Davis.加州大学戴维斯分校波士顿 1 型角膜假体的长期视力结果和并发症。
Ophthalmology. 2011 Aug;118(8):1543-50. doi: 10.1016/j.ophtha.2010.12.032. Epub 2011 Mar 12.
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Presumed endophthalmitis following Boston keratoprosthesis treated with 25 gauge vitrectomy: a report of three cases.波士顿角膜假体术后疑似眼内炎的 25G 玻璃体切割治疗:三例报告。
Graefes Arch Clin Exp Ophthalmol. 2010 Mar;248(3):447-50. doi: 10.1007/s00417-009-1230-3. Epub 2009 Dec 12.
7
Boston keratoprosthesis outcomes and complications.波士顿角膜假体的结果和并发症。
Cornea. 2009 Oct;28(9):989-96. doi: 10.1097/ICO.0b013e3181a186dc.
8
Successful prevention of bacterial endophthalmitis in eyes with the Boston keratoprosthesis.成功预防波士顿人工角膜植入眼的细菌性眼内炎。
Cornea. 2009 Sep;28(8):896-901. doi: 10.1097/ICO.0b013e3181983982.
9
Fungal colonization and infection in Boston keratoprosthesis.波士顿人工角膜中的真菌定植与感染
Cornea. 2007 Jan;26(1):9-15. doi: 10.1097/01.ico.0000224650.19837.25.
10
Results from the multicenter Boston Type 1 Keratoprosthesis Study.多中心波士顿1型人工角膜研究结果。
Ophthalmology. 2006 Oct;113(10):1779.e1-7. doi: 10.1016/j.ophtha.2006.05.015. Epub 2006 Jul 26.