Shi Hua, Wang Xiaojing, Wang Jianbo, Pan Jundi, Liu Junwei, Ye Bin
Department of Gastroenterology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, People's Republic of China.
Onco Targets Ther. 2016 Dec 8;9:7409-7414. doi: 10.2147/OTT.S118070. eCollection 2016.
The association between the hypermethylation of gene and gastric cancer risk has been investigated by a number of studies. However, the sample size of the majority of these studies was very small. To get a more a convincing conclusion, here we performed a meta-analysis of the previously published studies to assess the association between methylation and the risk of gastric cancer.
Eligible studies were identified by searching the MEDLINE/PubMed, Embase, and Web of Science databases before May 2016 without any language restriction. The strength of the association was estimated by odds ratio with its 95% confidence interval (CI).
Totally 1,399 samples, including 758 gastric cancer cases and 641 controls, from 13 studies were included in the present meta-analysis. Compared with non-cancer controls, the pooled OR of methylation in gastric cancer patients was 9.08 (95% CI: 6.40-12.88, <0.001), suggesting that the methylation of was significantly associated with increased risk of gastric cancer. Similar results were observed when subgroup analyses were performed stratified by country, ethnicity, and methylation testing methods.
Our meta-analysis showed a strong positive correlation between methylation and risk of gastric cancer, suggesting that methylation might be a promising biomarker for the diagnosis of gastric cancer.
多项研究已对某基因的高甲基化与胃癌风险之间的关联进行了调查。然而，这些研究中的大多数样本量都非常小。为了得出更有说服力的结论，我们对先前发表的研究进行了荟萃分析，以评估该基因甲基化与胃癌风险之间的关联。
通过检索2016年5月之前的MEDLINE/PubMed、Embase和Web of Science数据库来确定符合条件的研究，无语言限制。关联强度通过比值比及其95%置信区间（CI）进行估计。
本荟萃分析纳入了来自13项研究的总共1399个样本，包括758例胃癌病例和641例对照。与非癌症对照相比，胃癌患者中该基因甲基化的合并比值比为9.08（95%CI：6.40 - 12.88，P<0.001），表明该基因的甲基化与胃癌风险增加显著相关。当按国家、种族和甲基化检测方法进行亚组分析时，观察到了类似的结果。
我们的荟萃分析表明该基因甲基化与胃癌风险之间存在很强的正相关性，表明该基因甲基化可能是胃癌诊断的一个有前景的生物标志物。
