Georges George T, Nájera O, Sowers Kurt, Sowers James R
Diabetes and Cardiovascular Center, Department of Medicine, University of Missouri, Columbia, Mo., USA.
Department of Medicine, Touro University, Henderson, Nev., USA.
Cardiorenal Med. 2016 Nov;7(1):60-65. doi: 10.1159/000449476. Epub 2016 Sep 30.
Phosphorus is a key component of bone, and a deficiency results in poor mineralization along with other systemic symptoms of hypophosphatemia. Various causes of hypophosphatemia with renal wasting of phosphorus have been identified. These include the Fanconi syndrome, various genetic mutations of fibroblast growth factor 23 (FGF23) handling and the sodium/phosphate cotransporter, and those due to FGF23 secretion by mesenchymal tumors. Depending on the cause, vitamin D metabolism may also be impaired, which may amplify the deficiency in phosphorus and render treatment more challenging. Here, we report a case of hypophosphatemia and multiple stress fractures in a 20-year-old male college student living with chronic bone pain and anxiety about suffering further fractures. We further review the literature regarding this spectrum.
磷是骨骼的关键组成部分，磷缺乏会导致矿化不良以及低磷血症的其他全身症状。已确定多种导致磷经肾脏流失的低磷血症病因。这些病因包括范科尼综合征、成纤维细胞生长因子23（FGF23）处理及钠/磷共转运体的各种基因突变，以及间充质肿瘤分泌FGF23导致的病因。根据病因不同，维生素D代谢也可能受损，这可能会加重磷缺乏并使治疗更具挑战性。在此，我们报告一例20岁男性大学生患低磷血症及多处应力性骨折的病例，该患者长期遭受骨痛困扰，并担心会再次骨折。我们还进一步回顾了关于这一疾病谱的文献。
