Jiang Neng, Cui YongMei, Liu JunXiu, Zhu XiaoLin, Wu Hui, Yang Zheng, Ke ZunFu
Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Province Guangdong, P.R. China.
Department of Gynecology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Province Guangdong, P.R. China.
J Cancer. 2016 Oct 25;7(15):2213-2220. doi: 10.7150/jca.16539. eCollection 2016.
Tumor is one of the principal diseases that seriously threaten human health. Insight into sensitive cancer markers may open a new avenue for the early diagnosis and treatment of this disease. CTHRC1 has been identified as a cancer-related gene. It is a secretory glycoprotein that possesses multidimensional roles associated with wound repair, bone remodeling, hepatocytes fibrosis, adipose tissue formation, and so on. Our previous studies and numerous reports from other researchers have revealed that the ascended expression of CTHRC1 tends to go hand in hand with tumorigenesis, proliferation, invasion and metastasis in various human malignancies through a series of molecular mechanisms and signaling pathways. However, the detailed pathogenic mechanisms of CTHRC1 overexpression in human malignant cancers are not yet clear. Here, we shall focus our description on the functions, expression profile in several representative malignant tumors and a number of molecular mechanisms and signaling pathways involved with CTHRC1. This introductory discussion of CTHRC1 will serve as a reference for further research in understanding this intriguing cancer-related protein.
肿瘤是严重威胁人类健康的主要疾病之一。深入了解敏感的癌症标志物可能为这种疾病的早期诊断和治疗开辟一条新途径。CTHRC1已被确定为一种癌症相关基因。它是一种分泌性糖蛋白，具有与伤口修复、骨重塑、肝细胞纤维化、脂肪组织形成等相关的多维作用。我们之前的研究以及其他研究人员的众多报告表明，CTHRC1表达升高往往通过一系列分子机制和信号通路，与各种人类恶性肿瘤的发生、增殖、侵袭和转移密切相关。然而，CTHRC1在人类恶性肿瘤中过表达的详细致病机制尚不清楚。在此，我们将重点描述CTHRC1的功能、在几种代表性恶性肿瘤中的表达谱以及与之相关的一些分子机制和信号通路。对CTHRC1的这一介绍性讨论将为进一步研究理解这种有趣的癌症相关蛋白提供参考。
